Báo cáo khoa học: 1,5-Diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases
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1,5-Diamino-2-pentyne (DAPY) was found to be a weaksubstrateof grasspea (Lathyrus sativus,GPAO) andsainfoin(Onobrychis viciifolia, OVAO) amine oxidases. Prolongedincubations, however, resulted in irreversible inhibition ofboth enzymes. For GPAOandOVAO, rates of inactivationof 0.1–0.3 min)1were determined, the apparentKI values(half-maximal inactivation) were of the order of 10)5M.DAPY was found to be amechanism-based inhibitor of theenzymes because the substrate cadaverine significantly pre-vented irreversible inhibition. ...
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Báo cáo khoa học: 1,5-Diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases
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Báo cáo khoa học: 1,5-Diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases
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