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Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes

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Cone snails comprise500 species of venomous molluscs,which have evolved the ability to generate multiple toxinswith varied and often exquisite selectivity. One class,the a-conotoxins, is proving to be a powerful tool forthe differentiation of nicotinic acetylcholine receptors(nAChRs). These comprise a large family of complexsubtypes, whose significance in physiological functions andpathological conditions is increasingly becoming apparent.After a short introduction into the structure and diversity ofnAChRs, this overview summarizes the identification andcharacterization ofa-conotoxins with selectivity for neur......
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Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes

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