Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action
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The dimeric structure of seminal ribonuclease (BS-RNase)is maintained by noncovalent interactions and by twointersubunit disulfide bridges.Another unusual feature ofthis enzyme is its antitumour action, consisting in a cyto-toxic activity selective for malignant cells.This cytotoxicaction is exerted when the protein reaches the cytosol ofthe affected cells, where it degrades ribosomal RNA, thusblocking protein synthesis and leading cells to death.
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Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action
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Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action
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