Báo cáo khoa học: Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA-depleted cell lines
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Three pairs of parental (q+) and established mitochondrialDNAdepleted (q0) cells, derived frombone, lungandmusclewere used to verify the influence of the nuclear backgroundand the lack of efficient mitochondrial respiratory chain onantioxidant defences and homeostasis of intracellularreactive oxygen species (ROS). Mitochondrial DNA deple-tion significantly lowered glutathione reductase activity,glutathione (GSH) content, and consistently altered theGSH2: oxidized glutathione ratio in all of theq0cell lines,albeit todiffering extents, indicating themost oxidized redoxstate inboneq0cells....
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Báo cáo khoa học: Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA-depleted cell lines
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA-depleted cell lines
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