Báo cáo khoa học: Deadenylation of interferon-b mRNA is mediated by both the AU-rich element in the 3¢-untranslated region and an instability sequence in the coding region
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Viral infection of fibroblastic and endothelial cells leads tothe transient synthesis of interferon-b(IFN-b). The down-regulation of IFN-bsynthesis after infection results bothfrom transcriptional repression of the IFN-bgene and rapiddegradation of mRNA. As with many cytokine mRNAs,IFN-bmRNA contains an AU-rich element (ARE) in its3¢-untranslated region (UTR). AREs are known tomediatemRNAdeadenylation and destabilization. Depending onthe class of ARE, deadenylation was shown to occurthrough synchronous or asynchronous mechanisms....
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Báo cáo khoa học: Deadenylation of interferon-b mRNA is mediated by both the AU-rich element in the 3¢-untranslated region and an instability sequence in the coding region
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Deadenylation of interferon-b mRNA is mediated by both the AU-rich element in the 3¢-untranslated region and an instability sequence in the coding region
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