Báo cáo khoa học: Directed evolution of a glutaryl acylase into an adipyl acylase
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Semi-synthetic cephalosporin antibiotics belong to the top10 of most sold drugs, and are produced from 7-aminodes-acetoxycephalosporanic acid (7-ADCA). Recently newroutes have been developed which allow for the productionof adipyl-7-ADCA by a novel fermentation process. Tocomplete the biosynthesis of 7-ADCAa highly active adipylacylase is needed for deacylation of the adipyl derivative.Such an adipyl acylase can be generated from known glu-taryl acylases.
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Báo cáo khoa học: Directed evolution of a glutaryl acylase into an adipyl acylase
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Báo cáo khoa học: Directed evolution of a glutaryl acylase into an adipyl acylase
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