Báo cáo khoa học: Efficient inhibition of b-secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes
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Theb-amyloid peptide (Ab) is a major component oftoxic amyloid plaques found in the brains of patients withAlzheimer’s disease.Abis liberated by sequential cleavageof amyloid precursor protein (APP) byb-andc-secre-tases.The level of Abdepends directly on the hydrolyticactivity ofb-secretase.Therefore, b-secretase is an excel-lent target for drug design.An approach based on RNA-cleaving ribozymes was developed to control expressionofb-secretase.
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Báo cáo khoa học: Efficient inhibition of b-secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Efficient inhibition of b-secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes
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