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Báo cáo khoa học: Efficient RNA ligation by reverse-joined hairpin ribozymes and engineering of twin ribozymes consisting of conventional and reverse-joined hairpin ribozyme units

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In recent years major progress has been made in elucidating the mechanismand structure of catalytic RNA molecules, and we are now beginning tounderstand ribozymes well enough to turn them into useful tools. Work inour laboratory has focused on the development of twin ribozymes for site-specific RNA sequence alteration. To this end, we followed a strategy thatrelies on the combination of two ribozyme units into one molecule (hencedubbed twin ribozyme).
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Báo cáo khoa học: Efficient RNA ligation by reverse-joined hairpin ribozymes and engineering of twin ribozymes consisting of conventional and reverse-joined hairpin ribozyme units

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