Báo cáo khóa học: Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery–Dreifuss muscular dystrophy
Số trang: 11
Loại file: pdf
Dung lượng: 345.48 KB
Lượt xem: 7
Lượt tải: 0
Xem trước 2 trang đầu tiên của tài liệu này:
Thông tin tài liệu:
Loss of functional emerin, a nuclear membrane protein,causes X-linked recessive Emery–Dreifuss muscular dystro-phy. In a yeast two-hybrid screen, we found that emerininteracts with Btf, a death-promoting transcriptionalrepressor, which is expressedat high levels in skeletalmuscle.Biochemical analysis showed that emerin binds Btf with anequilibriumaffinity (KD)of100 nM. Using a collection of 21clustered alanine-substitution mutations in emerin, the resi-dues required for binding to Btf mapped to two regions ofemerin that flank its lamin-binding domain. ...
Nội dung trích xuất từ tài liệu:
Báo cáo khóa học: Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery–Dreifuss muscular dystrophy
Nội dung trích xuất từ tài liệu:
Báo cáo khóa học: Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery–Dreifuss muscular dystrophy
Tìm kiếm theo từ khóa liên quan:
Report medicine traditional medicine scientific reports gastric cancer hormone medicine tumor cellsGợi ý tài liệu liên quan:
-
Investigating the prognostic and predictive value of the type II cystatin genes in gastric cancer
17 trang 32 0 0 -
9 trang 20 0 0
-
63 trang 19 0 0
-
Báo cáo khoa học: Programmed cell death Apoptosis and alternative deathstyles
13 trang 19 0 0 -
Encyclopedia of Medical Anthropology
1119 trang 19 0 0 -
9 trang 17 0 0
-
13 trang 17 0 0
-
11 trang 16 0 0
-
12 trang 15 0 0
-
Báo cáo khoa học: Lpx1p is a peroxisomal lipase required for normal peroxisome morphology
11 trang 14 0 0