Báo cáo khoa học: Gradual phosphorylation regulates PC4 coactivator function
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The unstructured N-terminal domain of the transcriptional cofactor PC4contains multiple phosphorylation sites that regulate activity. The phos-phorylation status differentially influences the various biochemical func-tions performed by the structured core of PC4. Binding to ssDNA isslightly enhanced by phosphorylation of one serine residue, which is notaugmented by further phosphorylation.
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Báo cáo khoa học: Gradual phosphorylation regulates PC4 coactivator function
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Báo cáo khoa học: Gradual phosphorylation regulates PC4 coactivator function
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