Phân tích tư tưởng của nhân dân qua đoạn thơ: Những người vợ nhớ chồng… Những cuộc đời đã hóa sông núi ta trong Đất nước của Nguyễn Khoa Điềm
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Testican-1, a secreted proteoglycan enriched in brain, has asingle thyropin domain that is highly homologous todomains previously shown to inhibit cysteine proteases. Wedemonstrate that purified recombinant human testican-1 is astrong competitive inhibitor of the lysosomal cysteine pro-tease, cathepsin L,withaKiof 0.7nM, but it does not inhibitthe structurally related lysosomal cysteine protease cathep-sin B. Testican-1 inhibition of cathepsin L is independent ofits chondroitin sulfate chains and is effective at both pH 5.5and7.2.At neutral pH, testican-1also stabilizes cathepsin L,slowing pH-induced denaturation and allowing the proteaseto remain active longer, although the rate of proteolysis isreduced. ...
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Báo cáo khoa học: Human proteoglycan testican-1 inhibits the lysosomal cysteine protease cathepsin L
