Báo cáo khoa học: Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway
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Heme is synthesized in all cell types in aerobic organisms. Hydroxy-methylbilane synthase (HMBS) and uroporphyrinogen III synthase(UROS) catalyze two consecutive reactions in the heme biosynthetic path-way, generating the first linear and the first cyclic tetrapyrroles, respec-tively. Each of the HMBS and UROS genes contains the two separatepromoters that generate ubiquitous and erythroid-specific mRNAs.
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Báo cáo khoa học: Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway
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Báo cáo khoa học: Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway
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