Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells
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The urokinase-type plasminogen activator (uPA) receptor (uPAR) has beenimplicated in signal transduction and biological processes including cancermetastasis, angiogenesis, cell migration, and wound healing. It is a specificcell surface receptor for its ligand uPA, which catalyzes the formation ofplasmin from plasminogen, thereby activating the proteolytic cascade thatcontributes to the breakdown of extracellular matrix, a key step in cancermetastasis.
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Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells
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