Báo cáo khóa học: Interaction between the 2¢)5¢ oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1
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The human 2¢)5¢ oligoadenylate synthetases (OAS) form aconserved family of interferon-induced proteins consistingof four genes:OAS1, OAS2, OAS3and the 2¢)5¢ oligo-adenylate synthetase-like gene (OASL). When activated bydouble-strandedRNA,OAS1–3polymerizeATP into2¢)5¢-linkedoligoadenylates; 2¢)5¢-linkedoligoadenylates, in turn,activate a latent endoribonuclease that degrades viral andcellular RNAs. In contrast, while the p59 OASLprotein ishighlyhomologous to theOAS family (45%identity), its 350amino acid N-terminal domain lacks 2¢)5¢ oligoadenylatesynthetase activity. ...
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Báo cáo khóa học: Interaction between the 2¢)5¢ oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1
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Báo cáo khóa học: Interaction between the 2¢)5¢ oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1
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