Báo cáo khoa học: Membrane orientation of laminin binding protein An extracellular matrix bridging molecule of Leishmania donovani
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Earlier we presented several lines of evidence that a 67-kDalaminin binding protein (LBP) inLeishmania donovani,thatis different from the putative mammalian 67-kDa lamininreceptor, may play an important role in the onset of leish-maniasis, as these parasites invade macrophages in variousorgans after migrating through the extracellular matrix.Here we describe the membrane orientation of thisLeish-manialaminin receptor. Flowcytometric analysis using anti-LBP Ig revealed its surface localization, which was furtherconfirmed by enzymatic radiolabeling ofLeishmaniasurfaceproteins, autoradiography and Western blotting. ...
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Báo cáo khoa học: Membrane orientation of laminin binding protein An extracellular matrix bridging molecule of Leishmania donovani
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Báo cáo khoa học: Membrane orientation of laminin binding protein An extracellular matrix bridging molecule of Leishmania donovani
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