Báo cáo khoa học: Molecular and functional characterization of novel CRFR1 isoforms from the skin
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In our continued studies on corticotropin releasing factorreceptor (CRFR1) signaling in the skin, we tested functionalactivity of CRFR1a, e, f, g and h isoforms after transfectionto COS cells.Both membrane-bound and soluble variantsare translatedin vivointofinal proteinproducts that undergofurther post-translational modifications.CRFR1awas theonly isoform coupled directly to adenylate cyclase withthe exception of an artificial isoform (CRFR1h2) with theinsertion of 37 amino acids between the ligand bindingdomain and the first extracellular loop that was capable ofproducing detectable levels of cyclic AMP (cAMP)....
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Báo cáo khoa học: Molecular and functional characterization of novel CRFR1 isoforms from the skin
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Báo cáo khoa học: Molecular and functional characterization of novel CRFR1 isoforms from the skin
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