Báo cáo khoa học: nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications
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A large number of bioactive peptides have been isolatedfrom amphibian skin secretions. These peptides have avariety of actions including antibiotic and anticancer acti-vities and the inhibition of neuronal nitric oxide synthase.We have investigated the structure–activity relationship ofcitropin 1.1, a broad-spectrum antibiotic and anticanceragent that also causes inhibition of neuronal nitric oxidesynthase, by making a number of synthetically modifiedanalogues.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications
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