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Báo cáo khoa học: Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation

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To sustain life mammals have an absolute and continualrequirement for oxygen, which is necessary to produceenergy for normal cell survival and growth. Hence, main-tainingoxygen homeostasis is a critical requirement andmammals have evolved a wide range of cellular and phy-siological responses to adapt to changes in oxygen avail-ability. In the past few years it has become evident that thetranscriptional protein complex hypoxia-inducible factor(HIF) is a key regulator of these processes.
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Báo cáo khoa học: Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation

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