Báo cáo khoa học: Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression
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Oxidative stress, followed by the apoptotic death of pancreaticbcells, isconsidered to be one of causative agents in the evolution of the type 2 dia-betic state; therefore, the protection ofbcells can comprise an efficaciousstrategy for preventing type 2 diabetes. In the present study, RIN-m5F cells(i.e. the rat insulinoma bcell line) were stimulated with streptozotocin,resulting in a time- and concentration-dependent release of lactatedehydrogenase.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression
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