Báo cáo khoa học: Poly(ADP-ribose) The most elaborate metabolite of NAD+ Alexander Burkle
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One of the most drastic post-translational modification of proteins in eu-karyotic cells is poly(ADP-ribosyl)ation, catalysed by a family enzymestermed poly(ADP-ribose) polymerases (PARPs). In the human genome, 18different genes have been identified that all encode PARP family members.Poly(ADP-ribose) metabolism plays a role in a wide range of biologicalstructures and processes, including DNA repair and maintenance ofgenomic stability, transcriptional regulation, centromere function and mito-tic spindle formation, centrosomal function, structure and function of vaultparticles, telomere dynamics, trafficking of endosomal vesicles, apoptosisand necrosis. ...
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Báo cáo khoa học: Poly(ADP-ribose) The most elaborate metabolite of NAD+ Alexander Burkle
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Báo cáo khoa học: Poly(ADP-ribose) The most elaborate metabolite of NAD+ Alexander Burkle
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