Báo cáo khoa học: Redox-regulated affinity of the third PDZ domain in the phosphotyrosine phosphatase PTP-BL for cysteine-containing target peptides
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PDZ domains are protein–protein interaction modules that are crucial forthe assembly of structural and signalling complexes. They specifically bindto short C-terminal peptides and occasionally to internal sequences thatstructurally resemble such peptide termini. The binding of PDZ domains isdominated by the residues at the P0and P)2position within these C-ter-minal targets, but other residues are also important in determining specific-ity.
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Báo cáo khoa học: Redox-regulated affinity of the third PDZ domain in the phosphotyrosine phosphatase PTP-BL for cysteine-containing target peptides
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Redox-regulated affinity of the third PDZ domain in the phosphotyrosine phosphatase PTP-BL for cysteine-containing target peptides
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