Báo cáo khoa học: Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation
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Uniquely amongst vitamin K-dependent coagulation proteins, protein Cinteracts via its Gla domain both with a receptor, the endothelial cellprotein C receptor (EPCR), and with phospholipids. We have studiednaturally occurring and recombinant protein C Gla domain variants forsoluble (s)EPCR binding, cell surface activation to activated protein C(APC) by the thrombin–thrombomodulin complex, and phospholipiddependent factor Va (FVa) inactivation by APC, to establish if thesefunctions are concordant. ...
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Báo cáo khoa học: Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation
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Báo cáo khoa học: Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation
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