Báo cáo khoa học: Structure–function relationship of novel X4 HIV-1 entry inhibitors – L- and D-arginine peptide-aminoglycoside conjugates
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We present the design, synthesis, anti-HIV-1 and mode of action of neomy-cin and neamine conjugated at specific sites to arginine 6- and 9-mersd- and l-arginine peptides (APACs). The d-APACs inhibit the infectivityof X4 HIV-1 strains by one or two orders of magnitude more potently thantheir respective l-APACs.
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Báo cáo khoa học: Structure–function relationship of novel X4 HIV-1 entry inhibitors – L- and D-arginine peptide-aminoglycoside conjugates
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Báo cáo khoa học: Structure–function relationship of novel X4 HIV-1 entry inhibitors – L- and D-arginine peptide-aminoglycoside conjugates
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