Báo cáo khoa học: Symmetric fluoro-substituted diol-based HIV protease inhibitors Ortho-fluorinated and meta-fluorinated P1/P1¢-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacyy
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HIV-1 protease is a pivotal enzyme in the later stages of theviral life cycle which is responsible for the processing andmaturation of the virus particle into an infectious virion. Assuch,HIV-1proteasehasbecomean important target for thetreatment ofAIDS, and efficient drugs have beendeveloped.However, negative side effects and fast emerging resistanceto the current drugs have necessitated the development ofnovel chemical entities in order to exploit different phar-macokinetic properties as well as new interaction patterns....
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Báo cáo khoa học:Symmetric fluoro-substituted diol-based HIV protease inhibitors Ortho-fluorinated and meta-fluorinated P1/P1¢-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacyy
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học:Symmetric fluoro-substituted diol-based HIV protease inhibitors Ortho-fluorinated and meta-fluorinated P1/P1¢-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacyy
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