Báo cáo khoa học: The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated
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HIC1(hypermethylated in cancer 1) is a transcriptionalrepressor containing fiveKru¨ppel-likeC2H2zinc fingers andan N-terminal dimerization and autonomous repressiondomain called BTB/POZ. Here, we demonstrate that full-length HIC1 proteins are modified both in vivo andin vitrowith O-linkedN-acetylglucosamine (O-GlcNAc). This isa highly dynamic glycosylation found within the cytosolicand the nuclear compartments of eukaryotes. Analysis of[3H]Gal-labeled tryptic peptides indicates that HIC1 hasthree major sites forO-GlcNAc glycosylation....
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Báo cáo khoa học: The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated
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