Báo cáo Y học: Assignment of molecular properties of a superactive coagulation factor VIIa variant to individual amino acid changes
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Eur. J. Biochem. 269, 5950–5955 (2002) Ó FEBS 2002doi:10.1046/j.1432-1033.2002.03323.xThe most active factor VIIa (FVIIa) variants identified todate carry concurrent substitutions at positions 158, 296and298 with the intention of generating a thrombin-mimickingmotif, optionally combined with additional replacementswithin the protease domain [Persson, E., Kjalke, M. &Olsen, O. H. (2001)Proc. Natl Acad. Sci. USA98, 13583–13588]. Here we have characterized variants of FVIIamutatedat one or twoof these positions toassess the relativeimportance of the individual replacements.Assignment of molecular properties of a superactive coagulation factor VIIa variant to individual amino acid changesEgon Persson1 and Ole H. Olsen21Haemostasis Biology and 2Medicinal Chemistry Research IV, Novo Nordisk A/S,...
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Báo cáo Y học: Assignment of molecular properties of a superactive coagulation factor VIIa variant to individual amino acid changes
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Báo cáo Y học: Assignment of molecular properties of a superactive coagulation factor VIIa variant to individual amino acid changes
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