Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism
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Fructose 2,6-bisphosphate (Fru-2,6-P2) plays an importantrole in the regulation of major carbohydrate fluxes as bothallosteric activator and inhibitor of target enzymes. Toexamine the role of Fru-2,6-P2in the regulation of hepaticcarbohydrate metabolism in vivo,Fru-2,6-P2 levels wereelevated in ADM mice with adenovirus-mediated overex-pression of a double mutant bifunctional enzyme, 6-phos-phofructo-2-kinase/fructose-2,6-bisphosphatase (n¼6), incomparison to normal control mice (control,n¼6). ...
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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism
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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism
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