Phân tích tư tưởng của nhân dân qua đoạn thơ: Những người vợ nhớ chồng… Những cuộc đời đã hóa sông núi ta trong Đất nước của Nguyễn Khoa Điềm
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A new human/rat CRH analogue has been synthesizedusing the Fmoc/tBu solid-phase synthetic protocol. Thesequence ofthe new peptide differs from the original intwo positions, 12 and 15, at which the native amino acidsL-phenylalanine 12 and L-leucine 15 have been replacedby the nonprotein amino acids D-phenylalanine anda-aminoisobutyric acid (Aib), respectively. The highresolution three-dimensional solution structure of[D-Phe12, Aib15]CRH has been determined by 688 dis-tance constraints (656 meaningful NOE and 32 H-bondsdistance limits) and 21 angle constraints. ...
Nội dung trích xuất từ tài liệu:
Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists
