Báo cáo Y học: Study of substrate specificity of human aromatase by site directed mutagenesis
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Human aromatase is responsible for estrogen biosynthesisand is implicated, in particular, in reproduction and estro-gen-dependent tumor proliferation. Themolecular structuremodel is largelyderived fromtheX-ray structure of bacterialcytochromes sharing only 15±20% identities withhP-450arom. In the present study, site directed mutagenesisexperiments were performed to examine the role of K119,C124, I125, K130, E302, F320, D309, H475, D476, S470,I471 and I474 of aromatase in catalysis and for substratebinding....
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Báo cáo Y học: Study of substrate specificity of human aromatase by site directed mutagenesis
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Báo cáo Y học: Study of substrate specificity of human aromatase by site directed mutagenesis
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