Báo cáo Y học: The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity
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Ammodytoxins (Atxs) are presynaptically acting snakevenom phospholipase A2 (PLA2) toxins the molecularmechanism of whose neurotoxicity is not completelyunderstood. Two chimeric PLA2s were prepared by repla-cing the C-terminal part of a nontoxic venom PLA2,ammodytin I2, with that of AtxA(K108N). The chimeraswere not toxic, but were able to bind strongly to an Atxs-specific neuronal receptor, R25.
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Báo cáo Y học: The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity
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Báo cáo Y học: The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity
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