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Diastereoselective synthesis of novel 2,5-dioxopyrrolidine derivatives via biocatalytic domino reactions
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A series of novel 2,5-dioxopyrrolidines were synthesized by the one-pot reaction of coumarin-3-carboxylic acids 1 with thiourea derivatives and alkyl isocyanides in the presence of Fe 3 O4 NPs @ lipase as heterogeneous reusable nanobiocatalysts with high yields. Multicomponent reactions (MCRs) are useful tools for the efficient synthesis of heterocyclic compounds due to their environmental friendliness, atomic economy, and green specifications.
Nội dung trích xuất từ tài liệu:
Diastereoselective synthesis of novel 2,5-dioxopyrrolidine derivatives via biocatalytic domino reactions
Nội dung trích xuất từ tài liệu:
Diastereoselective synthesis of novel 2,5-dioxopyrrolidine derivatives via biocatalytic domino reactions
Tìm kiếm theo từ khóa liên quan:
Journal of Chemistry Diastereoselective synthesis 2.5-dioxopyrrolidine derivatives Biocatalytic reactions Multicomponent reactions Green specificationsTài liệu liên quan:
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