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Effects of hydrophobic and electrostatic interactions on the escape of nascent proteins at bacterial ribosomal exit tunnel

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We study the escape process of nascent proteins at the ribosomal exit tunnel of bacterial Escherichia coli by using molecular dynamics simulations with coarse-grained and atomistic models. It is shown that the effects of hydrophobic and electrostatic interactions on the protein escape at the E. coli’s tunnel are qualitatively similar to those obtained previously at the exit tunnel of archaeal Haloarcula marismortui, despite significant differences in the structures and interactions of the ribosome tunnels from the two organisms.
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Effects of hydrophobic and electrostatic interactions on the escape of nascent proteins at bacterial ribosomal exit tunnel

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