Evaluation of acute and semi chronic toxicity of the remedy 'Bo phe dinh suyen QY' on experimental animals

To evaluate the acute toxicity and semi-chronic toxicity of the remedy “Bo phe dinh suyen QY” on experimental animals. Subjects and methods: The remedy “Bo phe dinh suyen QY” meeting basic standards was used to evaluate for acute toxicity in Swiss white mice, and for semi-chronic toxicity in Wistar white rats. Acute toxicity was assessed according to the Litchfield-Wilcoxon method. Sub-chronic toxicity was assessed according to the guidance of the Ministry of Health of Vietnam.
Nội dung trích xuất từ tài liệu:
Evaluation of acute and semi chronic toxicity of the remedy “Bo phe dinh suyen QY” on experimental animalshttps://doi.org/10.59459/1859-1655/JMM.335 EVALUATION OF ACUTE AND SEMI-CHRONIC TOXICITY OF THE REMEDY “BO PHE DINH SUYEN QY” ON EXPERIMENTAL ANIMALS Nguyen Thuong1 Nguyen Thanh Ha Tuan1*ABSTRACTPurpose: To evaluate the acute toxicity and semi-chronic toxicity of the remedy “Bo phe dinh suyen QY”on experimental animals.Subjects and methods: The remedy “Bo phe dinh suyen QY” meeting basic standards was used toevaluate for acute toxicity in Swiss white mice, and for semi-chronic toxicity in Wistar white rats. Acutetoxicity was assessed according to the Litchfield-Wilcoxon method. Sub-chronic toxicity was assessedaccording to the guidance of the Ministry of Health of Vietnam.Results: The remedy “Bo phe dinh suyen QY” at a dose of 375 g/kg mouse body weight/24 hours did notcause acute toxicity or death of experimental mice. For 28 consecutive days, rats administered “Bo phedinh suyen QY” at doses of 18.2 g/kg/day and 54.6 g/kg/day without affecting their general condition andhematological indices.Conclusions: The remedy “Bo phe dinh suyen QY” was safe in the assessment of acute toxicity (on mice)and semi-chronic toxicity (on rats).Keywords: Bo phe dinh suyen QY, acute toxicity, experiment.Corresponding Author: Nguyen Thanh Ha Tuan, Email: nguyentuan000010@gmail.comReceipt date: July 24, 2023; scientific review: July 2023; accepted: August 15, 2023.1 Military Hospital 1031. INTRODUCTIONS Traditional Medicine, Military Hospital 103 showed Acute respiratory infection is a common disease, that the remedy was safe and had good anti-mostly in the Winter-Spring season. Unpredictable, inflammatory, cough-reducing, expectorant effects,dry, too hot or too cold weather is often the condition and quickly reduced clinical symptoms. However,for an increase in respiratory infections, mainly the the remedy has not yet been thoroughly researchedupper respiratory tract. If upper respiratory tract and evaluated for safety and effectiveness.infection is not detected and treated promptly, it can We conducted this study to evaluate theeasily lead to lower respiratory tract infection with acute and semi-chronic toxicity of the remedy onsymptoms of difficulty breathing, rapid breathing, experimental animals.wheezing, bronchiolitis, and pneumonia [1].Traditional medicine has many methods to treat 2. SUBJECTS AND METHODSacute respiratory infections, such as acupuncture, 2.1. Subjects and materialssauna, traditional medicine... Western medicine - Subjects: adult Swiss white mice (weighing 18-has a quick relief effect, but it is still difficult to limit 20g/mouse) and adult Wistar white rats (weighingthe recurrence of the disease. Traditional medicineremedies for treating acute respiratory infections 180-200g/mouse). Research animals were providedare safe and effective, often playing an important and raised by the Animal Department, Vietnamrole in practice. Military Medical University according to research animal standards. The remedy “Bo phe dinh suyen QY” wasdeveloped based on the dialectical treatment of - Materials: The remedy “Bo phe dinh suyen QY”traditional medicine on schistosomiasis, combined was extracted into liquid extract according to basicwith modern medical knowledge on the causes standards. Ingredients of the remedy “Bo phe dinhand pathogenesis of respiratory tract infection suyen QY” (total 130g) include: Saphoshnikovia[1], [2]. Initial results of clinical trials using the divaricata 10g, Scutellaria baicalensis 8g,remedy “Bo phe dinh suyen QY” in the treatment Rehmannia glutinosa 10g, Glycyrrhiza uralensis 5g,of acute respiratory infections at the Department of Platycodon grandiflorum 8g, Stemona tuberosa 8g,56 Journal of MILITARY MEDICINE, Number 368 (01-02/2024)Eucalyptus (Rhizoma Atractylodis macrocephalae) group) were given distilled water to drink. Rats10g, Astragalus Astragali (Radix Astragali of group treatment 1 were administered “Bo phemembranacei) 15g, Radix Angelicae sinensis 10g, dinh suyen QY” at a dose of ...