In situ synthesis and characterization of nano-hydroxyapatite/starch composites

Nano-hydroxyapatite/starch composite was synthesized using in situ precipitation. Starch concentration effect on the structure of composite was examined. Characterization of the obtained samples, The X-ray diffraction and Fourier transform infrared spectroscopy demonstrated the purity of the formed nano-HA in the starch matrix. Morphology studies of the samples, checked by field emission scanning electron microscope and transmission electron microscope, show the effects of starch on the size, shape, and morphology of hydroxyapatite nanoparticles.
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In situ synthesis and characterization of nano-hydroxyapatite/starch compositesCite this paper: Vietnam J. Chem., 2023, 61(S1), 51-56 Research articleDOI: 10.1002/vjch.202200213 In situ synthesis and characterization of nano-hydroxyapatite/starch composites Nguyen Thi Lan Huong1*, Phan Dinh Tuan1, Phan Thi Ngoc Bich2, Nguyen Minh Thao3, Mai Thanh Tung4 Ho Chi Minh University of Natural Resources and Environment, 1 236B, Le Van Sy, Ward 1, Tan Binh District, Ho Chi Minh City 70000, Viet Nam 2 Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10000, Viet Nam3Dong Thap University, 783 Pham Huu Lau, Ward 6, Cao Lanh city, Dong Thap Province 81000, Viet Nam 4 Hanoi University of Sciences and Technology, No. 1, Dai Co Viet, Hai Ba Trung Hanoi 10000, Viet Nam Submitted November 24, 2022; Revised February 22, 2023; Accepted March 13, 2023Abstract Nano-hydroxyapatite/starch composite was synthesized using in situ precipitation. Starch concentration effect on thestructure of composite was examined. Characterization of the obtained samples, The X-ray diffraction and Fouriertransform infrared spectroscopy demonstrated the purity of the formed nano-HA in the starch matrix. Morphology studiesof the samples, checked by field emission scanning electron microscope and transmission electron microscope, show theeffects of starch on the size, shape, and morphology of hydroxyapatite nanoparticles. Keywords. Composite, hydroxyapatite, starch, in situ precipitation.1. INTRODUCTION engineering. Compared with other polymers, this polymer is biodegradable, biocompatible, andHydroxyapatite (Ca10(PO4)6(OH)2 - HA) is an helpful inexpensive.[13,14] In HA/starch composites, the polarbiomaterial with potential orthopedic, dental, and character of starch providing strong support formaxillofacial applications, because of its valuable adhesion between the HA and starch. In this work, inbiocompatibility, bioactivity, and osteoconductivity. situ precipitation of HA/starch composite, starchHA, with similarity in chemical and structural concentration effect on the final structure andcharacterization considering inorganic component of characterization of the prepared composites arebone, enamel, and dentin has received considerable reported.attention from the biologists and biomaterialscientists.[1] In recent years, many interests have been 2. EXPERIMENTALattracted by HA which is embedded in polymermatrixes to enhance its applications.[2-4] Organic 2.1. Materials and methodsmaterials surfaces could be modified achievedifferent properties, such as the ability of carrying The chemical used in this study including Ca(OH)2,functional groups, chelate to metal ions by their H3PO4, starch, absolute ethanol were pure for analysisfunctional groups and hydrophilicity.[5-8] A composite (China). They were used without any furtherbiomaterial of HA and polymer therefore is awaited purification.to show HA nanoparticles dispersed uniformly in the HA/starch nanocomposites containing variouspolymer matrix and increase biocompatibility, HA contents (10, 40, and 70 wt.% samples werebiodegradation.[9-12] named as HA-10, HA-40 and HA-70, respectively) In biomedical field, biopolymers are an important were synthesized using in situ precipitation at roommaterials source. Starch is useful biopolymer for temperature. At first, starch was dissolved in double -some applications such as bone replacement implants, distilled water at a concentration of 5 %w/v, andbone cements, drug delivery and scaffolds for tissue stirred for 30 min at 70oC. The Ca(OH)2 suspension51 Wiley Online Library © 2023 Vietnam Academy of Science and Technology, Hanoi & Wiley-VCH GmbH 25728288, 2023, S1, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/vjch.202200213 by Readcube (Labtiva Inc.), Wiley Online Library on [01/05/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by ...