Incidence of total hip and total knee replacements from the prospective epidemiologic risk factor study: Considerations for event driven clinical trial design
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Osteoarthritis (OA) leads to joint failure and total joint replacement (TJR, either hip (H) or knee (K)). Worsening of pain and joint space narrowing are believed to be surrogates for joint failure; however, we hypothesize that TJR, as a reflection of joint failure, can be used as an endpoint in event-driven clinical trials within a reasonable duration.
Nội dung trích xuất từ tài liệu:
Incidence of total hip and total knee replacements from the prospective epidemiologic risk factor study: Considerations for event driven clinical trial design
Nội dung trích xuất từ tài liệu:
Incidence of total hip and total knee replacements from the prospective epidemiologic risk factor study: Considerations for event driven clinical trial design
Tìm kiếm theo từ khóa liên quan:
BMC Musculoskeletal Disorders Total joint replacements Clinical trial design Postmenopausal women Marginal significant effect sizeGợi ý tài liệu liên quan:
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