mir-331 negatively regulates thyroglobulin secretion via ERp29
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We investigated the effect of endoplasmic reticulum (ER) protein 29 (ERp29) on thyroglobulin (Tg) secretion and its negative regulation by microRNAs (miRNAs). ERp29 overexpression promoted Tg secretion from thyrocytes of PCCL3 cells via activation of ER stress sensors, including activation of transcription factor 6 fragmentation, XBP1 mRNA splicing by inositol-requiring enzyme 1, and phosphorylation of eukaryotic initiation factor 2 alpha as downstream actions of RNA-dependent protein kinase-like ER kinase. Thyroid hormone receptor beta is a target gene of mir-331, one of the most abundant miRNAs observed in ERp29-overexpressing cells.
Nội dung trích xuất từ tài liệu:
mir-331 negatively regulates thyroglobulin secretion via ERp29
Nội dung trích xuất từ tài liệu:
mir-331 negatively regulates thyroglobulin secretion via ERp29
Tìm kiếm theo từ khóa liên quan:
Journal of Zoology PCCL3 cells Endoplasmic reticulum stress microRNAs (miRNAs) Inositol-requiring enzyme 1Gợi ý tài liệu liên quan:
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