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Novel 'turn off-on' sensors for detection of DNA-acrylamide interaction using ZnS quantum dots as a phosphorescent probe

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A novel “turn off-on” sensor for detection of interaction between DNA and acrylamide (ACR) was developed. In this method, L-cysteine capped Mn-doped ZnS quantum dots (QDs) were used as room temperature phosphorescent probes. In the “turn-off” mode, ACR was absorbed onto the surface of QDs via electrostatic interaction, which caused a quenching effect of room-temperature phosphorescence signal by photoinduced electron-transfer mechanism. ACR was removed from the QDs’ surface with the addition of DNA. Thus, the phosphorescence emission of QDs was recovered and the system was turned to the “turn-on” mode.
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Novel “turn off-on” sensors for detection of DNA-acrylamide interaction using ZnS quantum dots as a phosphorescent probe

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