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OSTEOARTHRITIS - National clinical guideline for care and management in adults

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None of the newer evidence altered the priority given to metformin cited in the previousguideline. Although the specific cardioprotective effects of metformin suggested by the UKPDSstudy were open to challenge from some of the very recent studies, this was not on the basis ofstrong outcome data. Large observational studies from Canada and Scotland111,112 appeared tosupport the widespread advantage of metformin over sulfonylureas, but the A Diabetes OutcomeProgression Trial (ADOPT) study did not. The cardioprotective gains shown in the UKPDS andin the Scottish study far outweighed the concerns over lactic acidosis (provided renal functionwas adequate) in people with mild to moderate...
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OSTEOARTHRITIS - National clinical guideline for care and management in adults

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