Summary of Biology dotoral thesis: Study on cytotoxic activity of some cancer cell lines of isolated compounds from three soft corals Sinularia nanolobata, Sinularia leptoclados, Sinularia conferta collected from the sea area of Central Vietnam

The objectives of the thesis: Determine the chemical composition of three soft coral species S. nanolobata, S. conferta, S. leptoclados collected in the central sea of Vietnam; đetecting active substances with cytotoxic activity in soft corals studied, orienting their application for biomedical and pharmacological studies.
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Summary of Biology dotoral thesis: Study on cytotoxic activity of some cancer cell lines of isolated compounds from three soft corals Sinularia nanolobata, Sinularia leptoclados, Sinularia conferta collected from the sea area of Central VietnamMINISTRY OF EDUCATION VIETNAM ACADEMY OF AND TRAINING SCIENCE AND TECHNOLOGYGRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY ----------------------------- Ninh Thi Ngoc STUDY ON CYTOTOXIC ACTIVITY OF SOME CANCERCELL LINES OF ISOLATED COMPOUNDS FROM THREE SOFT CORALS SINULARIA NANOLOBATA, SINULARIA LEPTOCLADOS, SINULARIA CONFERTA COLLECTED FROM THE SEA AREA OF CENTRAL VIETNAM Major: Biochemistry Code: 9.42.01.16 SUMMARY OF BIOLOGY DOTORAL THESIS Ha Noi - 2021This thesis was completed at: Graduate university of Science andTechnology - Vietnam Academy of Science and Technology - Institute of Biotechnology - Institute of Marine BiochemistryAdvisor 1: PhD. Nguyen Hoai NamAdvisor 2: PhD. Tran My LinhReviewer 1: Assoc. Prof. PhD. Nguyen Dinh ThangReviewer 2: Assoc. Prof. PhD. Tran Thu HuongReviewer 3: PhD. Bui Thi Thuy LuyenThis thesis will be defended at Graduate University of Science andTechnology - Vietnam Academy of Science and Technology at hourdate month 2021.The thesis can be found in:- The Library of Graduate University of Science and Technology, VietnamAcademy of Science and Technology.- National Library of Vietnam.- Institute of Biotechnology 1 INTRODUCTION1. The urgency of the thesis In recent years, many countries have exploited bioactive substancesfrom marine organisms to serve researches to find drugs to treat dangerousdiseases such as cancer, hepatitis, and diseases infections and viruses. Up tothis point, a number of pharmaceuticals derived from marine organismshave reached the users hands, such as Cytarabine, Vidarabine, Eribulin,Trabectedin ... To achieve this achievement, research institutes around theworld has screened the biological activity of millions of compounds frommarine species, and invested financial resources and time in pre-clinical andclinical research phases for potential compounds. With the advantage of owning a long coastline of over 3.260 km alongwith many islands and bays, Vietnam has great potential for exploiting adiverse marine resources, rich in both species composition and storageamount. However, up to now, there are not many studies searching forvaluable active ingredients from Vietnamese marine organisms and limitedin the in vivo activity test step and research on drug-cell interactionmechanisms cancer. The studies are currently in the early stages comparedwith other countries in the region and far behind the advanced countries.The reason is that there are still some difficulties such as: surveying andcollecting samples of marine organisms requires modern equipment,compounds isolated from marine organisms often have very smallconcentrations, complex structures impurities, some compounds that areeasy to decompose right in the analysis process. Therefore, an urgentrequirement for our country is to develop research to step by step systemizethe chemical composition and biological activity of marine species. Genus Sinularia is one of the genus of soft corals that is interested inresearch by many scientists around the world. Up to now, there have beenmany studies on the chemical composition and biological activities of many 2compounds isolated from soft corals belonging to this genus. However,studies on many soft corals of the genus Sinularia such as S. nanolobata, S.leptoclados, S. conferta in Vietnam are few and almost no systematic andmethodical studies on these species mentioned above. Stemming from theabove fact, I chose the thesis topic Study on cytotoxic activity of somecancer cell lines of isolated compounds from three soft corals Sinulariananolobata, Sinularia leptoclados, Sinularia conferta collected from thesea area of Central Vietnam was chosen.2. The objectives of the thesis - Determine the chemical composition of three soft coral species S.nanolobata, S. conferta, S. leptoclados collected in the central sea ofVietnam. - Detecting active substances with cytotoxic activity in soft coralsstudied, orienting their application for biomedical and pharmacologicalstudies.3. The main contents of the thesis - Determine the scientific names of three soft corals collected from thesea area of Central Vietnam by molecular markers. - Isolation and Determination of chemical structures of isolatedcompounds from three soft corals S. nanolobata, S. conferta, S. leptoclados. - Evaluation of cytotoxic activity in vitro of isolated compounds ...