Summary of Chemistry dotoral thesis: Study on chemical constituents and biological activities of Trichosanthes baviensis, Trichosanthes anguina, and Trichosanthes kirilowii

The objectives of the thesis: Study on chemical constituents of three Trichosanthes species (T. baviensis, T. anguina, and T. kirilowii) grown in Vietnam; evaluation of cytotoxic and tyrosinase enzyme inhibitory activities of isolated compounds from the above mentioned Trichosanthes species.
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Summary of Chemistry dotoral thesis: Study on chemical constituents and biological activities of Trichosanthes baviensis, Trichosanthes anguina, and Trichosanthes kirilowii MINISTRY OF EDUCATION VIETNAM ACADEMY OF AND TRAINING SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY ----------------------------- Hoang Thi Yen Hoàng Thị Yến STUDY ON CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF Trichosanthes baviensis, Trichosanthes anguina AND Trichosanthes kirilowii. Major: Organic chemistry Code: 9.44.01.14 SUMMARY OF CHEMISTRY DOTORAL THESIS Hanoi - 2019 2 27 This thesis was completed at: Graduate University of Science and LIST OF PUBLISHED ARTICLES Technology, Vietnam Academy of Science and Technology 1. Nguyen Xuan Nhiem, Hoang Thi Yen, Bui Thi Thuy Luyen, Bui Huu Tai, Pham Van Hoan, Nguyen Phuong Thao, Hoang Le Tuan Anh, Ninh Khac Ban, Phan Van Kiem, Chau Van Minh, Advisor 1: Prof. Chau Van Minh Jang Hoon Kim, Jeon Mi Ni and Young Ho Kim. Chemical Advisor 2: PhD. Nguyen Xuan Nhiem components from the leaves of Trichosanthes baviensis and their tyrosinase inhibitory activity. Bulletin of the Korean chemical society, 2015, 36 (2), 703-706. 2. Nguyen Xuan Nhiem, Hoang Thi Yen, Phan Van Kiem, Chau Van Minh, Bui Huu Tai, Hoang Le Tuan Anh, SeonJu Park, Nanyoung Kim, and Seung Hyun Kim. 1H and 13C NMR Reviewer 1: assignments of tricanguinas A -B, coumarin monoterpenes from Trichosanthes anguina L. Magnetic Resonance in Chemistry, Reviewer 2: 2014, 53(2), 178-180. 3. Chau Van Minh, Nguyen Xuan Nhiem, Hoang Thi Yen, Phan Van Reviewer 3: Kiem, Bui Huu Tai, Hoang Le Tuan Anh, Truong Thi Thu Hien, SeonJu Park, Nanyoung Kim, and Seung Hyun Kim. Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities. Archives of Pharmacal Research, 2015, 38(8), 1443- 1448. This thesis will be defended at Graduate University of Science and 4. Hoang Thi Yen, Hoang Le Tuan Anh, Duong Thi Hai Yen, Pham Technology, Vietnam Academy of Science and Technology at hour Hai Yen, Duong Thi Dung, Do Thi Ha, Phan Van Kiem, Chau date month 2019. Van Minh, Nguyen Xuan Nhiem. Phenolic glycosides from Trichosanthes baviensis. Journal of Medicinal Materials, 2014, 19(5), 283-287. The thesis can be found in: 5. Hoang Thi Yen, Hoang Le Tuan Anh, Dan Thi Thuy Hang, Pham - The Library of Graduate University of Science and Technology, Hai Yen, Pham Thi Trang Tho, Do Thi Ha, Phan Van Kiem, Vietnam Academy of Science and Technology. Chau Van Minh, Nguyen Xuan Nhiem. Megastigmane glycosides - Vietnam National Library. from Trichosanthes anguina L.. Journal of Medicinal Materials, 2014, 19(5), 299-303. 26 3 cytotoxic activity on A-549 cell line with IC50 of 2.7 µM, stronger INTRODUCTION than those of mitoxantrone (IC50 of 7.2 µM). Compounds TK1, TK6 Vietnam is located in a tropical monsoon climate, and TK8 exhibited moderate cytotoxic activity with IC50 values mountainous and hilly terrain, so the climate conditions are also very ranging from 14.7 to 49.4 µM. Compounds TK2 and TK3 exhibited diverse, with many typical and sub-climatic regions. These factors weak cytotoxic activity on the cell lines A-549 and HT-29. effect on ecological conditions, dense, moist, evergreen, or sparse, semi-deciduous tropical vegetation and subtropical vegetation in the RECOMMENDATIONS high mountain areas. From the results of chemical constituents and biological According to estimates of Vietnamese botanists, there are activities of T. baviensis, T. anguina and T. kirilowii, we demonstrate about 12,000 species in Vietnam, of which, about one third is used as that: ...