Summary of doctoral thesis in Material science: Synthesis and luminescent properties characterization of nanomaterials based on NaYF4 matrices containing Er3+ and Yb3+ for biomedical application

The layout of the thesis: In addition to the introduction, conclusion, list of symbols and abbreviations, list of tables, list of images and drawings, list of published works related to the thesis. Project, appendices and references.
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Summary of doctoral thesis in Material science: Synthesis and luminescent properties characterization of nanomaterials based on NaYF4 matrices containing Er3+ and Yb3+ for biomedical application s MINISTRY OF EDUCATION VIETNAM ACADEMY OF SCIENCE AND TRAINING AND TECHNOLOGY GRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY ----------------------- Ha Thi Phuong SYNTHESIS AND LUMINESCENT PROPERTIES CHARACTERIZATION OF NANOMATERIALS BASED ON NaYF4 MATRICES CONTAINING Er3+ AND Yb3+ FOR BIOMEDICAL APPLICATION Major: Optical, optoelectronic and photonic materials Code: 9 44 01 27 SUMMARY OF DOCTORAL THESIS IN MATERIAL SCIENCE Hanoi – 2019 The thesis has been completed at: Institute of Materials Science - Vietnam Academy of Science and Technology Science supervisors: 1. Dr. Tran Thu Huong 2. Prof. Dr. Le Quoc Minh Reviewer 1: Assoc. Prof. Dr. ….. Reviewer 2: Prof. Dr. ………… Reviewer 3: Assoc. …………… The thesis was defended at Evaluation Council held at Graduate University of Science and Technology - Vietnam Academy of Science and Technology on, 2019. Thesis can be further referred at: - The Library of Graduate University of Science and Technology. - National Library of Vietnam. 1 INTRODUCTION Nowadays, there are many applications of nanomaterials and products made of nanomaterials such as material science, energy, environment, electronics and especially in biomedical sciences. In biomedical science, luminescent nanomaterials could make flouorescent labelling possible and effective. Notably, in the last few years, many types of nanomaterials have become the current subjects of basic and applied research, such as nanomaterials containing rare-earth upconversion nanophosphors (UCNP). When stimulating this materialby infrared light, radiant emission will be aborted in the visible region. Therefore, they have become one of the new and recognized research objects in many sectors such as health care, security, energy .... When applying in the health care sector, the UCNP has two specific advantages compared to other luminescent materials. First of all, using infrared stimulation sources minimizes the object's self-emitting ability and enhances the contrast of micro-images. In addition, infrared light is safer for human body, which does not cause cell changes, and it can penetrate a few millimeters into human tissue, which will make a deeper intervention into the affected area. There are many published works on UCNP types, in which oxide, fluoride base materials of ytri and gadoli rare-earth ion-doped Er3+, Yb3+, Tm3+, Ho3+ are more prominent. Studies show that nanometer-sized NaYF4 network will create upconversion luminescent effect with high, durable and luminescent performance in different conditions. This material promises many potential applications bio security, optoelectronic and especially in biomedical as image recognition (bioimaging), biological sensors (biosensing), therapy Cancer (cancer therapy). Biological identification applications in vitro and in vivo of rare earth ionic doped UCNP have high contrast ratio. Therefore, UCNP materials have great potential in designing and manufacturing biological nano complexes. Very accurately identify some types of cancer cells. In the world, some researchers’ groups collected UCNP materials in sizes ranging from a few tens to several hundred nm, luminescent green areas, fingerprint recognition applications, drug guides, nanoscale oil or they could be used in association with biomarkers that could test certain types of cells such as lung cancer cells, Hela cells. In particular, many UCNP materials of several hundred nm can mark nm-sized cells by extracellular method. Because the structure, luminescent properties and biological conjugation are some of the determinants of biomedical application, the study of these factors has always played an important role in material production. Studies in Vietnam on luminescent nanomaterials containing rare soil. Although those research have been just able to access nanotechnology, they have made important changes, creating new attraction for scientists. For upconversion nanophosphors luminescent nanomaterials, several research groups have investigated UCNPs containing Er, Yb, Tm ions, with oxides of ytri, sodiumytrifloride substrate. These works mainly on the synthesis method, structure, size and shape as well as the characteristics and mechanisms of fluorescence upconversion in a multi-photon form with the orientation of the application in imaging, optoelectronics, security printing and some research results applied in the energy industry. However, the problem of applying UCNP in cancer detection and treatment is not much. The question is how to use upconversion nanophosphors into biomedical and choose which solution is suitable for the process of functionalization, conjugation with biological activity objects. How does the combination of nanotechnology and biology allow the application of nano-sized fluorescent materials for the purpose of detecting and detecting biological molecules used in biomedical sensors and images? 2 For all the above mentioned points, I selected the topic of research on nanomaterials containing rare earth upconverted luminescence application in medical biology as the content for the thesis with the title: Synthesis and luminescent properties characterization of nanomaterials based on NaYF4 matrices containing Er3+ and ...