Summary of the Metarial sciensce theis: Study on preparation of biocompatibale hydroxyapatite coatings on titanium substrate by sol-gel method

The thesis was designed to find appropriate technological conditions such as pH of solution, calcination temperature, firing time, measures of titanium metal surface treatment to fabricate hydroxyapatite coatings. (HA and FHA) on titanium substrate by solgel method capable of applying biomedical.
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Summary of the Metarial sciensce theis: Study on preparation of biocompatibale hydroxyapatite coatings on titanium substrate by sol-gel method MINISTRY OF VIETNAM ACADEMY OF EDUCATION SCIENCE AND TECHNOLOGY AND TRAININGGRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY ----------------------------------- NGO THI ANH TUYET STUDY ON PREPARATION OF BIOCOMPATIBALE HYDROXYAPATITE COATINGS ON TITANIUM SUBSTRATE BY SOL-GEL METHOD. Scientific Field: Metal Classification Code: 9.44.01.29SUMMARY OF THE METARIAL SCIENSCE THEIS Hà Nội – 2019 The thesis was completed at: Graduate University of science and technology- Vietnam Academy of ScienceScientific Supervisors: 1.Dr. Nguyen Ngoc Phong 2.Dr. Pham Thi San1st Reviewer2nd Reviewer:3rd Reviewer:The thesis will be defended at Graduate University of ScienceAnd Technology, Vietnam Academy of Science andTechnology, 18 Hoang Quoc Viet, Cau Giay District, HanoiCity.At… hour… date… month… 2019The Thesis can be found in National Library of Vietnam andlibrary of Graduate University of Science And Technology,Vietnam Academy of Science and Technology 1INTRODUCTION In recently, biocompatible metal materials used in orthopedicsurgery has been widely studied in the world. Due to the aging of thepopulation in developed countries and the desire for patients tomaintain a high quality life, and advances in the synthesis ofmaterials and surgical procedures that allow implants materials areapplied in many different ways. Therefore, the demand for high-performance implants to apply for cardiovascular, traumatic,orthopedic, spinal and dental problems has increased significantly. In2012, worldwide, the market for bio-implant materials reached about94.1 billion USD and by 2010 it was about 134.3 billion USD.Therefore, scientists are focusing on investigating to create newbiomedical materials with good features. Implants used in orthopedictechniques are often made of metal materials due to their higherhardness and mechanical strength compared to organic materials orcomposite materials. Among biological implant materials, titaniumand titanium alloys are considerably used in orthopedic implants dueto its excellent properties such as low density, high perfomance, lowelectrical conductivity, high corrosion resistance. However, titaniumand its alloy are impossible to bond biochemically with bone. Inorder to improve the properties and over-come the disadvantages oftitanium and its alloy in biomedical applications, scientists havestudied the compatibility layers coated on titanium and its alloys.Hydroxyapatite (HA) coatings on titanium and its alloys substratewas synthesised to provide the necessary conditions for bonding withtissues and prevent the release of metal ions from substrates whenusing in dental and orthopedic implant. Hydroxyapatite [HA, Ca10(PO4)6(OH)2] or fluor-hydroxyapatite [FHA Ca10(PO4)6(OH)2-xFx] wherein 0≤ x ≤ 2 with 2HA by replacing F- for OH- which is attracted considerable attentiondue to its excellent bioactivity. HA has similar chemical compositionwith the mineral component of natutal bone tissue with ratio Ca / P =1.67. In-vivo studies of HA coating showed that HA can improvebone growth amount of cells and tissues of the bone in the orthopedicand dental implants. There are some methods to prepare HA coatingon titanium such as plasma spraying, ion pumps, sputtering, sol-gelmethod, the cathode deposition method, the anodized method,plasma electron oxidation (PEO)… In Viet Nam, the HA coatings for biomedical purposes havewidely studied. However, the results shown that, most of studies donot demand the practical application. Therefore, we propose thethesis with entitle: “STUDY ON PREPARATION OFBIOCOMPATIBALE HYDROXYAPATITE COATINGS ONTITANIUM SUBSTRATE BY SOL-GEL METHOD”.The main contents and objectives of the thesis We focus on the sol-gel method to fabricate biocompatiblecoatings based on titanium substrate with high compatible property. The thesis was designed to find appropriate technologicalconditions such as pH of solution, calcination temperature, firingtime, measures of titanium metal surface treatment to fabricatehydroxyapatite coatings. (HA and FHA) on titanium substrate by sol-gel method capable of applying biomedical. Influence of the parameters such as pH, temperature,concentration of electrolyte solution, viscosity ...on the coatingformation will be studied. Characterizations of the coating will bestudied by TEM, SEM, EDS, and X-ray, Adhesionstrength…Electrochemical properties of the coating will be analyzed 3by anodic polarization measurements, electrochemical impedancespectroscopy. Study to improve the adhesion strength of HA coating by themodification of suface of Ti substarte or using titanium poroussubstrate, or replace OH- group with F- to create FHA layer. Biocompatibility of coating layer will be investigated in-vitro in SBF. While, in vivo investigates were performed in Rabits.The new contributions of the thesis:-The relationship of the technological parameters and features of thematerial has been carefully studied, thereby clarifying the researchresults and making the process of manufacturing HA and FHA withbasic parameters.- Improved quality of coating has been studied by manufacturingintermediate TiO2, Ti porous and FHA layers.- In-vivo and in-vitro tests with good results are a good first step forthe study of practical application in the future.• In terms of application: A technological process has b ...