Summary of thesis on doctor of medicine: Research into morphological features and some special pulse sequence on brain magnetic resonance in alzheimer patients

Practical questions put forward by clinicians in the past have been researched and settled in the thesis. The AD diagnosis is completely based on clinics and the implementation of clinical tests for the diagnosis work depends on assessors’ subjectivity. Therefore, the development of MRI techniques shall help clinicians make diagnosis more quickly and objectively.
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Summary of thesis on doctor of medicine: Research into morphological features and some special pulse sequence on brain magnetic resonance in alzheimer patients MINISTRY OF EDUCATION AND TRAINING MINISTRY OF HEALTH HANOI MEDICAL UNIVERSITY NGOC TRAN VAN RESEARCH INTO MORPHOLOGICAL FEATURES AND SOME SPECIAL PULSE SEQUENCE ON BRAIN MAGNETIC RESONANCE IN ALZHEIMER PATIENTS Specialism : Radiology Diagnosis Code : 62720166 SUMMARY OF THESIS ON DOCTOR OF MEDICINE HANOI – 2021 Research completed at: HANOI MEDICAL UNIVERSITY Scientific instructors: ASSOC. PROF & PHD THANG PHAM ASSOC. PROF & PHD LUU VU DANG Defender 1: Defender 2: Defender 3: The Thesis shall be defended at the PhD Council of Medicine at Hanoi Medical University At on 2021 The Thesis can be found at: - National Library; - Library of Hanoi Medical University 1 INTRODUCTION Alzheimer disease is the degeneration pathology of the central nerve system with features of gradually increasing but unrecoverable progression. It causes the memory loss, cognitive disorder, and changes in behaviors, which affects patients’ occupation and social lives. Current criteria for Alzheimer disease is mainly diagnosed based on such three globally accepted current clinical criteria as DSM V1, ICD X2, NINCDS-ADRDA3. Magnetic resonance images (MRI) can be considered as paraclinical tests relevant to Alzheimer disease diagnosis as they allow to precisely measure the brain weight in 3 directions (3D), especially the size of the hippocampus and related areas5 as well as image changes in AD patients based on their diffusion, spectro, and perfusion. Therefore, the development of image diagnosis methods by MRI for Alzheimer disease in the pre-clinical stage is very vital and pressing, especially for the 3 pulse sequences: diffusion, spectro, and perfusion. This has brought about a positive imaging method in AD diagnosis. Some researchers in Vietnam have initially studied the MRI morphology. However, none of them has utilized such pulse sequences as: diffusion, spectro, and perfusion to quantify changes in brain images in AD patients. We have conducted the theme: “Research into morphological features and some special pulse sequences on brain magnetic resonance in Alzheimer disease patients” in order to: 1. Description of brain’s morphological features in Alzheimer disease patients; 2. Analysis of magentic resonance features like diffusion, perfusion, and spectro in Alzheimer disease patients’ brains. 3. Assessment on changes in pulse sequences of brain magnetic resonance in Alzheimer disease patients based on other age, gender, and disease level variables. 1. The thesis’s topicality Practical questions put forward by clinicians in the past have been researched and settled in the thesis. The AD diagnosis is completely based on clinics and the implementation of clinical tests for the diagnosis work depends on assessors’ subjectivity. Therefore, the development of 2 MRI techniques shall help clinicians make diagnosis more quickly and objectively. Besides, parameters of pulse sequences of Diffusion-weighted imaging show the number of AD infected people patients quickly increases in countries worldwide in general and in Vietnam in particular. This causes pressure for diagnosis, cares, and treatment. The search for an early and precise diagnosis method is necessary. The thesis orients toward changes in AD patients’ brains compared to those people with normal brains based on MRI filming, especially the application of pulse sequences of diffusion, spectro, and perfusion. Although the benefits of using MRI to diagnose AD have been studied and pointed out by many researchers, there have been remained several inconsistent viewpoints and assessment by researchers in the world. The benefits need further researching in machines of new generations and higher magnetics whereas there haven't been any researches into these three pulse sequences in Vietnam yet. 2. The thesis’s new contributions The use of clinical diagnostic tests causes many difficulties in diagnosis, especially at those places where there are not specialists. Results from brain MRI of our AD patients may help clinicians gain more foundations for AD diagnosis in line with the Vietnamese’s parameters. The T13D pulse sequence shows differentiation in AD patients’ brain morphology compared to that in the control group in terms of changes in MTA, IUD, B, E Indicators, and especially the volume of the hippocampus. The clinicians may base on these to make diagnosis. This is the first research in Vietnam with diffusion, spectro, and perfusion that utilizes MRI to quantify changes in AD patients’ brains and point out clear differentiation compared to those in the control group. By measuring the changes in these pulse sequences, it is easy to identify brain injuries caused by AD. These Indicators may suggest identifying the parameters to diagnose AD as well as those in Vietnamese people with normal brains. The conclusions of this research do not only help radiologists gain foundations for identification of brain injuries in AD patients on MRI image films, especially on diffusion, spectro, and perfusion but help 3 clinicians and researchers in diagnosing, treating, following up and making other researches into AD patients as well. 3. The thesis’s lay-out The thesis is 150 page thick. In addition to the questioning (3 pages), the conclusion part (2 pages), ...