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Synthesis and in vitro cytotoxic activity of novel pyrazolo[1,5-a]pyrimidines and related Schiff bases
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The newly synthesized compounds were characterized and confirmed by analytical and spectroscopic data (IR, MS, 1H NMR, and 13C NMR). Pyrazolo[1,5-a]pyrimidines 5a–c and 9a–c and Schiff bases 11b–f were investigated for their cytotoxicity against four human cancer cell lines (colon HCT116, lung A549, breast MCF-7, and liver HepG2) according to SRB assay and the structure–activity relationship was discussed.
Nội dung trích xuất từ tài liệu:
Synthesis and in vitro cytotoxic activity of novel pyrazolo[1,5-a]pyrimidines and related Schiff bases
Nội dung trích xuất từ tài liệu:
Synthesis and in vitro cytotoxic activity of novel pyrazolo[1,5-a]pyrimidines and related Schiff bases
Tìm kiếm theo từ khóa liên quan:
Journal of Chemistry 5-Aminopyrazole Ferrocenyl-2-carboxaldehyde Schiff bases Antitumor activityTài liệu liên quan:
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