Synthesis, computational drug likeness, DFT studies and in vitro biological activity evaluation of some heteronuclear complexes of functionalized (E)-2-(butan-2-ylidene) hydrazinecarbothioamide ligand
Số trang: 18
Loại file: pdf
Dung lượng: 1.28 MB
Lượt xem: 10
Lượt tải: 0
Xem trước 2 trang đầu tiên của tài liệu này:
Thông tin tài liệu:
The melting points of the complexes were >350oC, indicating high thermal stability. Cu-Zn-containing complex showed the least binding energy against the three proteins. The bioactivity scores of the complexes were between -0.50 and 0.0. Against A549 Cu-Zn, Co-Zn and Fe-Zn containing complexes showed potential activity. Against MCF-7, Fe-Cu containing complex had IC50 of 53.5 whereas Co-Zn containing complex was active against HepG2. Three complexes were active against S. aureus in the tested range.
Nội dung trích xuất từ tài liệu:
Synthesis, computational drug likeness, DFT studies and in vitro biological activity evaluation of some heteronuclear complexes of functionalized (E)-2-(butan-2-ylidene) hydrazinecarbothioamide ligand
Nội dung trích xuất từ tài liệu:
Synthesis, computational drug likeness, DFT studies and in vitro biological activity evaluation of some heteronuclear complexes of functionalized (E)-2-(butan-2-ylidene) hydrazinecarbothioamide ligand
Tìm kiếm theo từ khóa liên quan:
Biological activity Molecular docking Principal component analysis principal component analysis Computational drug likeness predictionGợi ý tài liệu liên quan:
-
19 trang 92 0 0
-
Neolignans and flavonol glycosides from the leaves of Viburnum lutescens blume
8 trang 36 0 0 -
Chemical constituents from the stem barks of Polyscias serrata balf
8 trang 33 0 0 -
Ebook Applied linear algebra (Second edition): Part 2
377 trang 23 0 0 -
A data analytics approach to player assessment
19 trang 22 0 0 -
81 trang 21 0 0
-
Ebook Pattern Recognition and Machine Learning: Part 2 - Christopher M. Bishop
380 trang 19 0 0 -
Forecasting SET50 index with multiple regression based on principal component analysis
24 trang 18 0 0 -
Recognition of human faces and temperatures based on automatically intelligent algorithm
6 trang 18 0 0 -
Research on deep learning and its application in stock price prediction
11 trang 18 0 0