The role of climate and out-of-Africa migration in the frequencies of risk alleles for 21 human diseases
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Demography and environmental adaptation can affect the global distribution of genetic variants and possibly the distribution of disease. Population heterozygosity of single nucleotide polymorphisms has been shown to decrease strongly with distance from Africa and this has been attributed to the effect of serial founding events during the migration of humans out of Africa.
Nội dung trích xuất từ tài liệu:
The role of climate and out-of-Africa migration in the frequencies of risk alleles for 21 human diseases
Nội dung trích xuất từ tài liệu:
The role of climate and out-of-Africa migration in the frequencies of risk alleles for 21 human diseases
Tìm kiếm theo từ khóa liên quan:
BMC Genetics Environmental adaptation Human disease risk loci Positive selection Genome-wide association studies Serial founder effectTài liệu liên quan:
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