Treatment of Inflammatory Bowel Disease in Childhood: Best Available Evidence

The most common identifiable cause of ACS in this study waspulmonary fat embolism (PFE).4 Originally described in traumavictims, PFE is a frequent complication of bone fracture and mayprogress to involve the lungs and CNS with multiorgan failure anddeath.10,11 The NACSS made the diagnosis by using BAL toidentify fat-laden macrophages; less-invasive means of making thediagnosis are not well established, and even the specificity offat-laden macrophages in BAL specimens has been questioned.12Vichinsky et al,13 in the first systematic, prospective search for PFEin sickle cell disease, found that 44% of patients with moderate-to-severe ACS had PFE as a probable etiology. These patients hadlonger,...
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Treatment of Inflammatory Bowel Disease in Childhood: Best Available Evidence