An IGF-1R-mTORC1-SRPK2 signaling Axis contributes to FASN regulation in breast cancer
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Fatty acid synthase (FASN) expression is associated with a more aggressive breast cancer phenotype and is regulated downstream of receptor tyrosine kinase (RTK) signaling pathways. Recently, post transcriptional regulation of lipogenic transcripts have been demonstrated as being mediated downstream of serine-arginine rich protein kinase 2 (SRPK2), which acts to phosphorylate serine-arginine rich splicing factors (SRSFs), resulting in RNA binding and various RNA regulatory processes.
Tìm kiếm theo từ khóa liên quan:
BMC Cancer Fatty acid synthase Breast cancer Receptor tyrosine kinase Serine-arginine rich protein kinase 2 RNA regulatory processesGợi ý tài liệu liên quan:
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