Báo cáo hóa học: Lasers, stem cells, and COPD

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Lasers, stem cells, and COPD
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Báo cáo hóa học: "Lasers, stem cells, and COPD"Lin et al. Journal of Translational Medicine 2010, 8:16http://www.translational-medicine.com/content/8/1/16 REVIEW Open AccessLasers, stem cells, and COPDFeng Lin1†, Steven F Josephs1†, Doru T Alexandrescu2†, Famela Ramos1, Vladimir Bogin3, Vincent Gammill4,Constantin A Dasanu5, Rosalia De Necochea-Campion6, Amit N Patel7, Ewa Carrier6, David R Koos1* Abstract The medical use of low level laser (LLL) irradiation has been occurring for decades, primarily in the area of tissue healing and inflammatory conditions. Despite little mechanistic knowledge, the concept of a non-invasive, non- thermal intervention that has the potential to modulate regenerative processes is worthy of attention when search- ing for novel methods of augmenting stem cell-based therapies. Here we discuss the use of LLL irradiation as a “photoceutical” for enhancing production of stem cell growth/chemoattractant factors, stimulation of angiogenesis, and directly augmenting proliferation of stem cells. The combination of LLL together with allogeneic and autolo- gous stem cells, as well as post-mobilization directing of stem cells will be discussed.Introduction (Personal Perspective) this mini-review to discuss what we believe to be rele- vant to investigators attracted by the concept of “regen-We came upon the field of low level laser (LLL) therapy erative photoceuticals”. Before presenting our synthesisby accident. One of our advisors read a press releaseabout a company using this novel technology of specific of the field, we will begin by describing our rationale forlight wavelengths to treat stroke. Given the possible role approaching COPD with the autologous stem cell basedof stem cells in post-stroke regeneration, we decided to approaches we are developing.cautiously investigate. As a background, it should be COPD as an Indication for Stem Cell Therapysaid that our scientific team has been focusing on thearea of cord blood banking and manufacturing of dispo- COPD possesses several features making it ideal forsables for processing of adipose stem cells for the past 3 stem cell based interventions: a) the quality of life andyears. Our board has been interested in strategically lack of progress demands the ethical exploration ofrefocusing the company from services-oriented into a novel approaches. For example, bone marrow stem cellsmore research-focused model. An unbiased exploration have been used in over a thousand cardiac patients withinto the various degenerative conditions that may be some indication of efficacy [1,2]. Adipose-based stemaddressed by our existing know-how led us to explore cell therapies have been successfully used in thousandsthe condition of chronic obstructive pulmonary disease of race-horses and companion animals without adverse(COPD), an umbrella term covering chronic bronchitis effects [3], as well as numerous clinical trials areand emphysema, which is the 4th largest cause of death ongoing and published human data reports no adversein the United States. As a means of increasing our prob- effects (reviewed in ref [4]). Unfortunately, evaluation ofability of success in treatment of this condition, the stem cell therapy in COPD has lagged behind otherdecision was made to develop an adjuvant therapy that areas of regenerative investigation; b) the underlyingwould augment stem cell activity. The field of LLL ther- cause of COPD appears to be inflammatory and/orapy attracted us because it appeared to be relatively immunologically mediated. The destruction of alveolarunexplored scientific territory for which large amounts tissue is associated with T cell reactivity [5,6], pathologi-of clinical experience exist. Unfortunately, it was difficult cal pulmonary macrophage activation [7], and auto-anti-to obtain the cohesive “state-of-the-art” descr ...