Báo cáo khoa học: 15-Deoxy D12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor c in human erythroleukemia cells
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In humans, thromboxane (TX) A2 signals through two receptor isoforms,thromboxane receptor (TP)aand TPb, which are transcriptionally regula-ted by distinct promoters, Prm1 and Prm3, respectively, within the singleTP gene. The aim of the current study was to investigate the ability of theendogenous peroxisome proliferator-activated receptor (PPAR)c ligand15-deoxy-D12,14-prostaglandin J2 (15d-PGJ2) to regulate expression of thehuman TP gene and to ascertain its potential effects on the individual TPaand TPbisoforms....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: 15-Deoxy D12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor c in human erythroleukemia cells
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: 15-Deoxy D12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor c in human erythroleukemia cells
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